Boswellia serrata extract side effects, benefits, herbal supplement review, research studies, potencies, use for inflammation and joint health problems such as arthritis, osteoarthritis and other medical conditions
Boswellia is an herb that has boswellic acids. Various species are used in traditional herbal medicine in India and African countries for the treatment of a variety of diseases. Animal experiments show anti-inflammatory activity of the extract. The mechanism of this action is due to boswellic acids which are different from NSAIDs. Extracts from boswellia herb inhibit 5-lipoxygenase.
Take a boswellia supplement with food
Taking this product with a meal appears to help the absorption.
Effect of food intake on the bioavailability of boswellic acids from a herbal
preparation in healthy volunteers.
Planta Med. 2004; Sterk V, Büchele B. Department of Pharmacology of Natural Products & Clinical Pharmacology, University of Ulm, Ulm, Germany.
In this study we investigated the effects of concomitant food intake on the bioavailability of distinct boswellic acids from the test preparation BSE-018, a dry extract from Boswellia serrata gum resin. In a randomised, open, single-dose, two-way crossover study, healthy male subjects received three capsules of BSE-018 equivalent to 786 mg dry extract of Boswellia serrata gum resin either in the fasted state or together with a standardised high-fat meal. Boswellic acid plasma concentrations were analysed for up to 60 h after oral dosing. As compared to the fasted state, the administration of BSE-018 concomitantly with a high-fat meal led to several-fold increased areas under the plasma concentration-time curves as well as peak concentrations of beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid.
You can find this supplement in varying dosages and extract potencies.
Boswellia Extract (resin)
(standardized to contain 65% Boswellic Acids, 162.5mg.) 250mg
Boswellin (resin) (Extract of gum resins standardized to contain 65% (162 mg) Boswellic Acids)
buy Boswellia extract (tree resin), 65% Boswellic Acids 307 mg, 60 tablets
Raw material prices
There are many raw ingredient suppliers that sell boswellia serrata to vitamin companies. Here are examples of what is sold and the prices they are sold at.
Boswellia extract 15% at 11 dollars a kilogram
extract 65% at 18 dollars a kilogram
Gum resin extracts of Boswellia species have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases, and experimental data from animal models and studies with human subjects confirm the potential of boswellia extracts as a treatment inflammatory conditions but perhaps cancer.
Boswellia Serrata is an ancient Ayurvedic herb from India and known among herbalists as a treatment for arthritis. It is also beneficial in helping inflammation and joint health. Extracts of boswellia serrata have natural anti-inflammatory activity at sites where chronic inflammation is present by switching off pro-inflammatory cytokines and mediators, which initiate the process. Analysis of the ingredients of these extracts revealed that the pentacyclic triterpenes boswellic acids possess biological activities and appear to be responsible for the respective pharmacological actions.
Boswellia and asthma
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.
Eur J Med Res. 1998; Gupta I, Gupta V, Gupta S, Lüdtke R, Safayhi H, Ammon HP. Pharmakologie für Naturwissenschaftler, Pharmazeutisches Institut der Universität Tübingen, Tübingen, Germany.
The gum resin of Boswellia serrata, known in Indian Ayurvedic system of medicine as Salai guggal, contains boswellic acids, which have been shown to inhibit leukotriene biosynthesis. In a double-blind, placebo-controlled study forty patients, 23 males and 17 females in the age range of 18 - 75 years having mean duration of illness, bronchial asthma, were treated with a preparation of gum resin of 300 mg thrice daily for a period of 6 weeks. 70% of patients showed improvement of disease as evident by disappearance of physical symptoms and signs such as dyspnea, rhonchi, number of attacks, increase in FEV subset1, FVC and PEFR as well as decrease in eosinophilic count and ESR. In the control group only 27% of patients showed improvement. The data show a definite role of gum resin of Boswellia serrata in the treatment of bronchial asthma.
Boswellia serrata extract for the treatment of collagenous colitis. A double-blind, randomized, placebo-controlled, multicenter trial.
Int J Colorectal Dis. 2007; Madisch A, Miehlke S, Eichele O, Bethke B, Kuhlisch E, Bästlein E, Wilhelms G, Morgner A, Wigginghaus B, Stolte M. Medical Department I, Technical University Hospital, Dresden, Germany.
The objective of this study was to investigate the effect of Boswellia serrata extract on symptoms, quality of life, and histology in patients with collagenous colitis. Patients with chronic diarrhea and histologically proven collagenous colitis were randomized to receive either oral Boswellia serrata extract 400 mg three times daily for 6 weeks or placebo. Complete colonoscopy and histology were performed before and after treatment. Our study suggests that Boswellia serrata extract might be clinically effective in patients with collagenous colitis.
Boswellia and osteoarthritis
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
Phytomedicine. 2003; Kimmatkar N, Thawani V, Hingorani L. MS Orthopedics, Indira Gandhi Medical College, Nagpur, India.
Boswellia serrata tree is commonly found in India. The therapeutic value of its gum (guggulu) has been known. It posses good anti-inflammatory, anti-arthritic and analgesic activity. A randomized double blind placebo controlled crossover study was conducted to assess the efficacy, safety and tolerability of Boswellia serrata Extract in 30 patients of osteoarthritis of knee, 15 each receiving active drug or placebo for eight weeks. After the first intervention, washout was given and then the groups were crossed over to receive the opposite intervention for eight weeks. All patients receiving the herbal treatment reported decrease in knee pain, increased knee flexion and increased walking distance. The frequency of swelling in the knee joint was decreased. Radiologically there was no change. The observed differences between drug treated and placebo being statistically significant, are clinically relevant. Boswellia serrata Extract was well tolerated by the subjects except for minor gastrointestinal symptoms. Boswellia serrata Extract is recommended in the patients of osteoarthritis of the knee with possible therapeutic use in other arthritis.
Boswellia serrata review
Frankincense: systematic review.
BMJ. 2008; Ernst E. Complementary Medicine, Peninsula Medical School, Universities of Exeter and Plymouth, Exeter, UK.
All randomised clinical trials of Boswellia serrata extract as a treatment for any human medical condition were included and studies of Boswellia serrata preparations combined with other ingredients were excluded. Of 47 potentially relevant studies, seven met all inclusion criteria (five placebo controlled, two with active controls). The included trials related to asthma, rheumatoid arthritis, Crohn's disease, osteoarthritis, and collagenous colitis. Results of all trials indicated that Boswellia serrata extracts were clinically effective. Three studies were of good methodological quality. No serious safety issues were noted. The evidence for the effectiveness of Boswellia serrata extracts is encouraging but not compelling.
Boswellia side effects, is it safe?
No major boswellia serrata side effects have been mentioned in medical journals.
Can this herb be used together with cat's claw extract, msm, cmo, glucosamine, chondroitin and flax seed oil?
As long as the dosages are low or reasonable, the combinations should be acceptable.